COMPARISON OF SULFOBROMOPHTHALEIN (BSP) AND SULFOBROMOPHTHALEIN GLUTATHIONE (BSP-GSH) DISPOSITION UNDER CONDITIONS OF ALTERED LIVER-FUNCTION AND IN ISOLATED PERFUSED RAT-LIVER

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 87  (3) , 373-383
Abstract
Disposition of sulfobromophthalein (BSP) and sulfobromophthalein glutathione (BSP-GSH) was compared in control, phenobarbital, or .alpha.-naphthylisothiocyanate-(ANIT)-treated rats, and in the isolated perfused rat liver preparation. After dye administration, BSP-GSH had a more rapid early plasma disappearance rate, a more rapid appearance in the liver, and a greater rate of biliary excretion both in vivo and in the isolated perfused liver, than that of BSP. Hepatic uptake and biliary excretion of BSP-GSH are faster than that of BSP. Comparing BSP and BSP-GSH disposition after single bolus injection in rats treated with ANIT or phenobarbital, augmentation or reduction in plasma dye concentration, mean plasma half-life (2-30 min), hepatic dye content, and bile dye concentration, were of the same order of magnitude for both dyes. With dye infusion of 3.6 .mu.mol/kg per min, phenobarbital significantly enhanced the rate of biliary excretion of BSP but not BSP-GSH and ANIT treatment had a greater inhibitory effect on biliary excretion of BSP-GSH than BSP.