VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and VelociGene(R)- based Discovery of the Next Generation of Angiogenesis Targets

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Abstract
The concept that tumors can be controlled by directly targeting their vascular supply has finally come of age, because clinicaltrials using a humanized monoclonal antibody that blocks VEGF have demonstrated exciting efficacy in cancer patients,as well as in vascular eye diseases that can lead to blindness. However, data suggest that these current regimens may not providecomplete VEGF inhibition and, thus, that the maximum therapeutic potential of VEGF blockade has not yet beenachieved. We describe the status of a very potent and high-affinity VEGF blocker, termed the VEGF Trap, that may providethe opportunity to maximize the potential of VEGF blockade in cancer as well as in vascular eye diseases. We also describeuse of the VEGF Trap as a research tool, when coupled to high-throughput mouse genetics approaches such as VelociGene®that can be exploited in strategies to discover and validate the next generation of angiogenesis targets.