1H -NMRInvestigations on the Hydrogen Bond Formation between the Tranquilizers Diazepam and Nitrazepam and Some Nucleobases
Open Access
- 1 December 1978
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 33 (11-12) , 870-875
- https://doi.org/10.1515/znc-1978-11-1212
Abstract
The formation of hydrogen bonds between the minor tranquilizers diazepam and nitrazepam and a few nucleobases was studied in deuterochloroform solution by means of proton magnetic resonance spectroscopy. The thermodynamic and spectroscopic data of the associations were evaluated on the basis of a dimer model, using the concentration dependent shifts of the protons involved in hydrogen bonds. The interactions of nitrazepam (ΔH0= -10 to -21 k J/mol; ΔG25 0 - 0.2 to -7.4 kJ/mol) were found to be stronger than those of diazepam (ΔH0 = - 10 to - 13 kJ/mol; ΔG25 0 = 6.0 to 6.4 k j/mol). The various binding sites of the benzodiazepines for hydrogen bonds are discussed.Keywords
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