Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy

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Abstract
In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl--dependent and a late (200 ms-8 s) Cl--independent inhibition were shown to be present in the dentate. Enhancement of the late Cl--insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.