A Strategy for Measuring the Therapeutic Properties of New Antiparkinsonian Drugs, such as + PHNO, in Patients with On-Off Fluctuations
- 1 February 1989
- journal article
- review article
- Published by Wolters Kluwer Health in Clinical Neuropharmacology
- Vol. 12 (1) , 37-45
- https://doi.org/10.1097/00002826-198902000-00005
Abstract
Summary We describe a simple quantitative bedside method for assessing the dopaminergic properties of new therapeutic agents, namely, by documenting their duration of action in patients with Parkinson's disease who exhibit “on-off' fluctuations. This model represents a form of human dopaminergic “bioassay”.Keywords
This publication has 2 references indexed in Scilit:
- Efficacy of Rehabilitation in Parkinson's Disease Patients using the Unified Parkinson's Disease Rating Scale (UPDRS) and Three-dimensional Motion AnalysisThe Japanese Journal of Rehabilitation Medicine, 2010
- "ON-OFF" EFFECTS IN PATIENTS WITH PARKINSON'S DISEASE ON CHRONIC LEVODOPA THERAPYThe Lancet, 1976