Maintenance Antidepressant Therapy: A Double-Blind Comparison of Trazodone and Imipramine

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Abstract
A double-blind study of moderately to markedly depressed patients compared the long term efficacy and safety of trazodone with that of imipramine. Trazodone was found to be more effective than imipramine on several parameters used to measure efficacy. Patients developed minimal anticholinergic side effects with trazodone, as compared to imipramine, although patients receiving trazodone reported more drowsiness than did those on imipramine. Finally, there were no clinically significant changes in blood pressure, laboratory tests, serial EKG's, eye examinations, thyroid function, prolactin, or growth hormone. A higher percentage of trazodone patients continued on therapy throughout the full year of the study and had a superior clinical response in a number of areas. On the basis of this study and other available data, it appears that trazodone is a safe and effective antidepressant and can be used on a long term basis.

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