Effect of Angiotensin-Converting Enzyme Therapy on QT Interval Dispersion

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Abstract
Patients with chronic heart failure (CHF) have an increased risk for sudden death. This increased risk has been associated with increased QT dispersion (QTd), a reflection of the heterogeneity in ventricular repolarization. Angiotensin-converting enzyme (ACE) inhibitors have been reported to decrease heart size as well as decreasing morbidity and mortality in moderate-to-severe CHF. The aim of this study was to determine if ACE therapy is associated with a decrease in QTd, a marker for increased electrical instability. Ninety-seven patients were evaluated. The normalized QTd after 2 months of ACE therapy decreased from 16 ± 4 to 12 ± 3, a 25% reduction in dispersions. QTd also decreased from 61 ± 14 to 47 ± 12 (P P

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