Technique of Permanent Cannulation of the Right Ventricle in Rats and Ground Squirrels.

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Abstract
Summary Recently a technique for permanent cannulation of the aorta and vena cava was described which permits simultaneous blood sampling and circulatory studies in unanesthetized and undisturbed small animals. To make this technique usable for cardiac output determinations (Fick principle), the venous cannula is now permanently implanted in the right ventricle where mixing of the venous blood is adequate. Two hundred forty-one adult male rats and 61 adult ground squirrels of both sexes were cannulated in this way. Postoperative survival was 100%. The animals regained preoperative body weight after 3.9 days and continued afterwards to grow normally. Except for a few animals in which the cannula slipped from the ventricle into the atrium, the patency of the cannulas seemed to be limited only by the life span of the animal.

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