Massive splenomegaly responsive to proguanil and with features of hairy cell leukaemia
- 1 March 1995
- journal article
- case report
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 89 (2) , 194-196
- https://doi.org/10.1016/0035-9203(95)90492-1
Abstract
A recent Ethiopian immigrant to Israel presented with pneumococcal sepsis, massive splenomegaly and lymphadenopathy. Investigations revealed many features of both hairy cell leukaemia (HCL) and hyperreactive malarious splenomegaly (HMS). Proguanil therapy for HMS was followed by rapid, marked decrease in spleen size, disappearance of the tartrate-resistant acid phosphatase-positive cells characteristic of HCL, and increasing eosinophilia, but unchanged lymphadenopathy.Keywords
This publication has 14 references indexed in Scilit:
- Splenic lymphoma with villous lymphocytes in tropical West AfricaThe Lancet, 1992
- Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 casesBritish Journal of Haematology, 1991
- Use of immunoglobulin gene rearrangements to show clonal lymphoproliferation in hyper-reactive malarial splenomegalyThe Lancet, 1991
- Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome)Parasitology Today, 1986
- Reduction of Suppressor T Lymphocytes in the Tropical Splenomegaly SyndromeNew England Journal of Medicine, 1984
- Cell markers in hairy cell leukemia studied in cells from 51 patientsBlood, 1982
- The B‐Lymphocyte Nature of the Hairy Cell of Leukaemic ReticuloendotheliosisBritish Journal of Haematology, 1974
- Leukaemic Reticuloendotheliosis (‘Hairy’ Cell Leukaemia): A Distinct Clinico‐Pathological EntityBritish Journal of Haematology, 1974
- Tropical Splenomegaly Syndrome: Long-term Proguanil Therapy Correlated with Spleen Size, Serum IgM, and Lymphocyte TransformationBMJ, 1970
- An Investigation of Tropical Splenomegaly at Mulago Hospital, Kampala, UgandaBMJ, 1965