PLASMA-CONCENTRATIONS OF LIDOCAINE DURING INHALATION ANESTHESIA FOR FIBEROPTIC BRONCHOSCOPY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 60  (3) , 105-108
Abstract
The plasma concentration of lidocaine and its metabolite, mono-ethyl-glycine-xylidine, was measured during fiberoptic bronchoscopy (FB) using an ultrasonic nebulizer to achieve topical anesthesia. Most patients received additional anesthesia of the laryngeal region and the tracheobronchial tree during the procedure. The achieved plasma concentrations showed that a substantial amount of lidocaine was absorbed, but toxic plasma levels were not reached. Lidocaine plasma concentration above the therapeutic range for treating cardiac diseases was observed in 1 patient. The use of an ultrasonic nebulizer with lidocaine before FB seems to give sufficient local anesthesia and to be a safe method.

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