Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women

Open Access
Publisher Website
Google Scholar
Abstract
Objective: To determine the effect of obesity without the confounding effect of metabolic complications on the lipoprotein subclass profile in men and women. Design: Cross-sectional study. Subjects: A total of 40 lean (body mass index (BMI): 18.5–25 kg/m2) and 40 obese (BMI: 30–45 kg/m2) subjects, with blood pressure PPPP<0.05), with no difference in total HDL particle concentration. IDL and total LDL concentrations and LDL subclass distribution were not different between men and women. Conclusion: Obesity is associated with pro-atherogenic alterations in the lipoprotein subclass profile, which may increase cardiovascular disease risk even in the absence of classical metabolic risk factors. On the other hand, the female cardiovascular disease risk advantage is probably largely related to differences in traditional lipid risk factors (plasma triglyceride and HDL-cholesterol concentrations) because sex differences in the plasma lipoprotein subclass profile are minimal.

This publication has 72 references indexed in Scilit: