Haemolytic Anaemia to the Alpha-Interferon Treatment: A Proposed Mechanism
- 1 January 1993
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 65 (2) , 156-157
- https://doi.org/10.1159/000462407
Abstract
Auto-immune haemolytic anaemia (AIHA) has been found in a case of alpha-interferon treatment. Serum antibody and eluate were positive in the absence of the drug. Although the patient recovered after the treatment was stopped, DAGT remained positive for at least 8 months. The mechanism proposed to explain why this drug induced AIHA is similar to that proposed for alpha- methyl-dopa. Drugs could alter the red cell membrane and impair the immune system. Such changes have been observed with alpha-interferon and were related with increased autoimmunity.Keywords
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