Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins
- 10 March 1992
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 33 (11) , 1423-1426
- https://doi.org/10.1016/s0040-4039(00)91637-x
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Total synthesis of calicheamicinone: a solution to the problem of the elusive urethaneJournal of the American Chemical Society, 1990
- Installation of the allylic trisulfide functionality of the enediyne antibiotics. Thiol-induced reductive actuation of the Bergman processThe Journal of Organic Chemistry, 1990
- Experimental modeling of the priming mechanism of the calicheamicin/esperamicin antibiotics: actuation by the addition of intramolecular nucleophiles to the bridgehead double bondJournal of the American Chemical Society, 1989
- A core system that simulates the cycloaromatization and DNA cleavage properties of calicheamicin-esperamicin: a correlation experimentThe Journal of Organic Chemistry, 1989
- Esperamicins, a class of potent antitumor antibiotics: mechanism of action.Proceedings of the National Academy of Sciences, 1989
- Synthesis of a remarkably stable bicyclo[7.3.1]diynene esperamicin A1/calicheamicin .gamma. system. Structural requirements for facile formation of a 1,4-diylJournal of the American Chemical Society, 1988
- A model for the proposed mechanism of action of the potent antitumor antibiotic esperamicin A1Journal of the American Chemical Society, 1988
- Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1IJournal of the American Chemical Society, 1987
- Esperamicins, a novel class of potent antitumor antibiotics. 3. Structures of esperamicins A1, A2, and A1bJournal of the American Chemical Society, 1987
- Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1IJournal of the American Chemical Society, 1987