Liquid-chromatographic determination of aminoglutethimide in plasma.
Open Access
- 1 June 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 29 (6) , 1104-1105
- https://doi.org/10.1093/clinchem/29.6.1104
Abstract
A simple, rapid "high-performance" liquid-chromatographic procedure is presented for the determination of aminoglutethimide in plasma. After precipitation of the protein with acetonitrile, an aliquot of the supernate is injected directly onto a radially compressed, reversed-phase column. The aminoglutethimide is isocratically eluted with a mobile phase of acetonitrile/water/tert-butyl ammonium phosphate. The method is both accurate and precise and has been in routine use in our laboratory for more than 12 months.This publication has 1 reference indexed in Scilit:
- Serum Aminoglutethimide Levels: Studies of Serum Half‐Life, Clearance, and Patient ComplianceThe Journal of Clinical Pharmacology, 1979