Screening of organic acids in urine by chemical ionization mass spectrometry
- 1 February 1979
- journal article
- research article
- Published by Wiley in Journal of Mass Spectrometry
- Vol. 6 (2) , 47-56
- https://doi.org/10.1002/bms.1200060203
Abstract
A method has been developed for qualitative screening of carboxylic acids in human urine. The method uses direct chemical ionization mass spectrometry with isobutane as reagent gas. The carboxylic acids are separated from the urine samples by ion exchange. Normal carboxylic acid profiles have been determined and are compared with the profiles of patients suffering from certian metabolic disorders.Keywords
This publication has 17 references indexed in Scilit:
- Chemical ionization of amino acidsJournal of the American Chemical Society, 1976
- Effects of bifunctional interactions in the chemical ionization mass spectrometry of carboxylic acids and methyl estersJournal of Mass Spectrometry, 1976
- Quantitative metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry. Comparison of isolation methodsAnalytical Chemistry, 1975
- Chemical ionization mass spectra of amino acids and derivatives. Occurrence and fragmentation of ion‐molecule reaction productsJournal of Mass Spectrometry, 1973
- The mass spectra of carboxylic acids—VI: Metastable dissociations of isomeric ions in the mass spectra of oxalic and formic acids, and malonic and acetic acidsJournal of Mass Spectrometry, 1973
- The quantitative extraction and gas-liquid chromatographic determination of organic acids in urineThe Analyst, 1972
- Chemical ionization mass spectrometry of complex molecules. VIII. Esters of di- and tricarboxylic acidsAnalytical Chemistry, 1971
- Separation of amino acids in physiological fluids by two-dimensional thin-layer chromatographyClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- Chemical Ionization Mass Spectrometry. II. EstersJournal of the American Chemical Society, 1966
- ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA A DISEASE ENTITY IN CHILDHOODThe Lancet, 1963