Pharmacologic Effects of Angiotensin-II-amide on Aldosterone and Corticosterone Secretion by the Intact Anesthetized Rat1

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Abstract
Aldosterone and corticosterone were assayed by double isotope derivative dilution in serial samples of adrenal vein blood and in the entire adrenal gland alter collection, in groups of 4-6 intact, anesthetized male rats. Each animal served as its own control, and secretion rate was compared to the adrenal pool of each steroid to obtain the adrenal turnover rate. Chronic treatment with angiotensin-II-amide, 0.25 mg sc daily in oil for 14 days, caused highly significant increases in adrenal content and secretion of both aldosterone and corticosterone. The fractional adrenal turnover of aldosterone decreased, whereas that of corticosterone increased during stimulation. Acute infusions of angiotensin produced similar results and the aldosterone response preceded that of corticosterone. These pharmacologic effects may indicate a role of angiotensin or a related substance in the secretion of aldosterone by the intact rat.