Ring conformation and ester orientation in dihydropyrimidinecarboxylates: a combined theoretical (ab initio, density functional) and X-ray crystallographic study
- 1 June 1998
- journal article
- Published by Elsevier in Journal of Molecular Structure: THEOCHEM
- Vol. 432 (3) , 219-228
- https://doi.org/10.1016/s0166-1280(98)00061-x
Abstract
No abstract availableThis publication has 41 references indexed in Scilit:
- Calcium Entry Blockers and Activators: Conformational and Structural Determinants of Dihydropyrimidine Calcium Channel ModulatorsJournal of Medicinal Chemistry, 1995
- Conformational analysis of the 1,4-dihydropyridines linking the structural aspects to the biological binding event: a study of the receptor-site conformationJournal of Molecular Structure: THEOCHEM, 1994
- 100 years of the biginelli dihydropyrimidine synthesisTetrahedron, 1993
- Theoretical studies applicable to the design of novel anticonvulsantsJournal of Molecular Structure: THEOCHEM, 1993
- Theoretical studies applicable to the design of novel anticonvulsants: an AM1 molecular orbital structure–activity study of dihydropyridine calcium channel antagonistsCanadian Journal of Chemistry, 1992
- Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agentsJournal of Medicinal Chemistry, 1992
- 1,4‐Dihydropyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist ActivitiesAngewandte Chemie International Edition in English, 1991
- Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agentsJournal of Medicinal Chemistry, 1991
- Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridinesJournal of Medicinal Chemistry, 1990
- Structure and conformation of 1,4-dihydrobenzene, 1,4-dihydronaphthalene, and 9,10-dihydroanthracene. A theoretical studyThe Journal of Organic Chemistry, 1982