EXPERIMENTAL-INFECTION OF LABORATORY RODENTS AND CALVES WITH MICROFILARIAE OF ONCHOCERCA-GIBSONI

  • 1 January 1980
    • journal article
    • research article
    • Vol. 31  (1) , 82-86
Abstract
Uterine microfilariae of O. gibsoni migrated to skin of all parts of the body when inoculated in rats and mice. Higher microfilarial densities were obtained in the skin of mice compared with rats. In guinea pigs very few microfilariae migrated to the skin and densities of microfilariae were very low. Densities of skin microfilariae were lower in rats when inoculated i.p. compared with inoculation by 2 s.c. routes. In the latter case, higher densities of microfilariae were obtained in areas of skin closer to the injection sites. Persistence of microfilariae in the skin of rats was variable but only low numbers were recovered between 21-70 days after infection. Microfilariae migrated to the skin in calves experimentally infected by s.c. injection into the dewlap. Microfilaria were recovered consistently and in high numbers from skin snips along the ventral midline. Small numbers of microfilariae were occasionally found in skin snips from the dorsal midline.

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