ANALYSIS OF HERPES-SIMPLEX VIRUS ISOLATED FROM PATIENTS WITH RECURRENT HERPES KERATITIS EXHIBITING TREATMENT-RESISTANCE TO 5-IODO-2'-DEOXYURIDINE
- 1 January 1979
- journal article
- research article
- Vol. 23 (3) , 226-230
Abstract
Four strains of herpes simplex virus (HSV) were isolated from 2 patients with recurrent herpes keratitis who failed to respond to 5-iodo-2''-deoxyuridine (IDU) treatment. Of the 4 isolates, 2 were highly resistant to IDU in [African green monkey kidney] cell culture and the other 2 isolates were more susceptible to IDU than an HSV-1 laboratory strain. From each patient, an IDU-resistant and an IDU-susceptible virus was isolated. All 4 isolates were able to induce thymidine kinase (TK) activity in cell lines lacking that activity. All isolates were type 1 HSV, since the filamentous structures, recognized as a biological marker of type 2 HSV, were not observed in infected cells.This publication has 5 references indexed in Scilit:
- HERPES KERATITIS IN RABBITS: PATHOGENESIS AND EFFECT OF ANTIVIRAL NUCLEOSIDESAnnals of the New York Academy of Sciences, 2006
- Enzymatic basis for the selective inhibition of varicella-zoster virus by 5-halogenated analogues of deoxycytidineJournal of Virology, 1976
- Electron microscope observations on tubular structures in cells infected with herpes simplex virus type 2Archiv für die gesamte Virusforschung, 1976
- IN VIVO STUDIES WITH ANTIVIRAL AGENTS*Annals of the New York Academy of Sciences, 1965
- Mutant strains of herpes simplex deficient in thymidine kinase-inducing activityVirology, 1964