Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State
- 1 March 2009
- Vol. 17 (3) , 386-394
- https://doi.org/10.1016/j.str.2009.01.005
Abstract
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This publication has 56 references indexed in Scilit:
- Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and BackJournal of Molecular Biology, 2007
- Conformational entropy in molecular recognition by proteinsNature, 2007
- The mechanism of rate-limiting motions in enzyme functionProceedings of the National Academy of Sciences, 2007
- Substrate Recognition Reduces Side-Chain Flexibility for Conserved Hydrophobic Residues in Human Pin1Structure, 2007
- Dynamic Coupling and Allosteric Behavior in a Nonallosteric ProteinBiochemistry, 2006
- Ligand-dependent Dynamics and Intramolecular Signaling in a PDZ DomainJournal of Molecular Biology, 2004
- Molecular dynamics simulations of biomoleculesNature Structural & Molecular Biology, 2002
- Evidence for a Functional Role of the Dynamics of Glycine-121 ofEscherichia coliDihydrofolate Reductase Obtained from Kinetic Analysis of a Site-Directed MutantBiochemistry, 1997
- NMRPipe: A multidimensional spectral processing system based on UNIX pipesJournal of Biomolecular NMR, 1995
- Thermodynamic study of dihydrofolate reductase inhibitor selectivityBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994