Pulmonary clearance of inhaled 99mTc‐DTPA: effect of the detergent dioctyl sodium sulfosuccinate in aerosol

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Abstract
Summary. The influence of the detergent dioctyl sodium sulfosuccinate on clearance from the lungs of inhaled technetium‐99m‐labelled dietylenetriamine pentaacetate (99mTc‐DTPA) was studied in twelve rabbits. An aerosol of dioctyl sodium sulfosuccinate or its vehicle alone was administered for 5 min prior to aerosolized 99mTc‐DTPA via a bag‐in‐bottle system. Time‐activity curves were obtained from the right lung with a gamma camera. In rabbits given detergent, clearance of 99mTc‐DTPA was significantly faster than in rabbits given vehicle alone. No changes were seen in arterial Po2 and compliance. Our data indicates that the transfer of 99mTc‐DTPA from alveoli to blood can be accelerated by administration of the detergent dioctyl sodium sulfosuccinate without any dramatic change in surface tension. Clearance of 99mTc‐DTPA may be a very sensitive indicator of altered surfactant function.