Carbamazepine‐10,11‐Epoxide Determined by EMIT Carbamazepine Reagent
- 1 October 1980
- Vol. 21 (5) , 475-477
- https://doi.org/10.1111/j.1528-1157.1980.tb04298.x
Abstract
Carbamazepine-10,11-epoxide (CBZ-OX) was determined in physiological solutions by means of EMIT [enzyme multiplied immunoassay technique] carbamazepine reagent. It was recognized as 12-20% of the total amount, the cross-reaction being higher at lower CBZ-OX concentrations. A correction for CBZ-OX is necessary to correlate EMIT carbamazepine values was GLC values. The correction is relevant only for body fluids [human] other than plasma, since the unbound fraction of CBZ-OX would greatly influence the ultrafiltrate serum ratios.Keywords
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