κ-Opiate Agonist-Induced Inhibition of Gastrointestinal Transit in Different Strains of Mice

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Abstract
The effects of κ-opiate agonists on gastrointestinal motility was assessed in Swiss Webster, C57BL/6, BALB/c and DBA/2 strains of mice. The κ-agonists, PD 117302, U-69593 and U-50488H (3 mgkg–1), were injected subcutaneously and the distance travelled by a charcoal meal in the gastrointestinal tract was measured. All κ-agonists induced significant inhibition of charcoal meal transit; however, there were significant strain differences in the antitransit effect. It is concluded that κ-receptors are involved in the inhibition of gastrointestinal transit and that the negative data reported in the literature may be due to a genotype-dependent effect of κ-agonists.

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