Hydrogen-bond melting in B-DNA copolymers in a mean-field self-consistent phonon approach

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Abstract
We explore hydrogen-bond melting in B-DNA for the copolymers poly(dGC)-poly(dGC), poly(dAC)-poly(dGT), poly(dAG)-poly(dCT), and poly(dAT)-poly(dAT). Here dGC refers to a repeating sequence of a guanine base followed by a cytosine base on one strand. The melting is explored through a mean-field self-consistent phonon theory based on the Green’s-function method. By our calculations, the melting temperatures are 385, 366, 357, and 325 K for the four helices, respectively. The onset of melting, in helices with both A-T and G-C base pairs, is either in the A-T pair or in the G-C pair, depending on the effective near-neighbor interaction.