Cardiac Myosin Light Chains

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Abstract
The detection of circulating levels of cardiac myosin light chains (MLCs) recently has been proposed as a new biochemical marker of myocardial damage. In patients with unstable angina and acute myocardial infarction, measurement of MLCs seems to provide diagnostic information that differs from that obtained by determination of traditional cardiac enzymes and isoenzymes. In particular, there may be an advantage to measuring light chains, which are briefly influenced by reperfusion, instead of measuring the usual cytosolic enzymes for assessment of myocardial damage in patients treated with thrombolytic therapy. However, the definitive clinical utility and diagnostic performance of MLC determination in serum have not yet been established because of the lack of a simple and accurate assay for the measurement of this marker.

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