Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of Etoposide
- 1 January 1989
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 06 (5) , 408-412
- https://doi.org/10.1023/a:1015935532725
Abstract
Preformulation studies of etoposide, including pH–solubility profile, partition coefficient, pH–stability profile, and in vitrodissolution kinetics, were conducted to identify the responsible...This publication has 9 references indexed in Scilit:
- The Clinical Pharmacology of Etoposide and TeniposideClinical Pharmacokinetics, 1987
- Stability-indicating high-performance liquid chromatography of etoposide at various pH conditions using a reversed-phase octyl columnJournal of Chromatography A, 1987
- Program for Evaluating Drug Dissolution Kinetics in PreformulationPharmaceutical Research, 1985
- Etoposide: A Semisynthetic Epipodophyllotoxin Chemistry, Pharmacology, Pharmacokinetics, Adverse Effects and Use as an Antineoplastic AgentPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1984
- Review of etoposide.1983
- PHASE-I TRIAL OF A NEW FORM OF AN ORAL-ADMINISTRATION OF VP-16-2131979
- PHASE I CLINICAL-TRIAL OF AN ORAL SOLUTION OF VP-16-2131976
- A clinical trial of the oral form of 4′-demethyl-epipodophyllotoxin-β-D ethylidene glucoside (NSC 141540) VP 16–213Cancer, 1975
- Improved Holder for Intrinsic Dissolution Rate StudiesJournal of Pharmaceutical Sciences, 1965