Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis
- 1 April 1999
- journal article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 5 (2) , 134-136
- https://doi.org/10.1177/135245859900500211
Abstract
We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (w2=7.82), showing a significant effect (P50.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P50.03) of allele 1. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.Keywords
This publication has 11 references indexed in Scilit:
- The Future of Genetic Studies of Complex Human DiseasesScience, 1996
- A full genome search in multiple sclerosisNature Genetics, 1996
- A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complexNature Genetics, 1996
- A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22Nature Genetics, 1996
- An integrated metric physical map of human chromosome 19Nature Genetics, 1995
- A genetic basis for familial aggregation in multiple sclerosisNature, 1995
- Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's diseaseMolecular and Cellular Probes, 1994
- Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 allelesHuman Immunology, 1994
- Allele frequency distribution of the (TG)n(AG)m microsatellite in the apolipoprotein C-II geneGenomics, 1992
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983