Oxygen Affinity in Red Cells: Changes Induced in vivo by Propranolol
- 24 March 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4028) , 1372-1373
- https://doi.org/10.1126/science.175.4028.1372
Abstract
Propranolol, a blocking agent for the beta adrenergic receptor, produces a redistribution of 2,3-diphosphoglycerate in the red cell. At concentrations of 3.3 × 10 -5 M , 2,3-diphosphoglycerate in the red cell membrane becomes unbound in vitro. The administration of propranolol to humans produces similar changes and results in a decrease in the affinity of hemoglobin for oxygen.Keywords
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