The Abilities of Human Blood Platelets to Bind Extracellular Calcium and to be Aggregated by Adenosine Diphosphate are Related

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Abstract
A technique is described for preparing platelet rich plasma (PRP) containing a very low level of extracellular Ca. Using this Ca-depleted PRP, it was possible to demonstrate that extraplatelet Ca is in equilibrium with a small amount of Ca that is bound to the platelet surface. When Ca-depleted PRP is incubated at 37.degree. C, the platelets lose their ability to bind Ca. At the same time they lose their ability to aggregate. The binding of Ca to the platelet surface may be a prerequisite for ADP-induced aggregation.