A Methicillin-Resistant Strain ofStaphylococcus aureus

Publisher Website
Google Scholar
Abstract
Two cases of infection with the same strain of methicillin-resistant Staphylcoccus aureus are reported. Despite treatment with cephalothin, one of these patients died of his pulmonary infection. This strain of staphylococcus, referred to as the Seattle variant, was resistant to penicillin G, methicillin, erythromycin, chloramphenicol, tetracycline, streptomycin, kanamycin and cephalothin. Resistance to the penicillinase-resistant penicillins was primarily a reflection of a marked innate resistance in addition to extraordinary penicillinase production, sufficient to partially inactive methicillin. Prolonged incubation of antibiotic disc sensitivity plates may be required for the routine laboratory detection of methicillin-resistant staphylococci. Clinical experiences with similar strains around the world are reviewed and the possible usefulness of antibiotic combinations is discussed.

This publication has 2 references indexed in Scilit: