Effect of Aliphatic Polyamines on Growth and Macromolecular Syntheses in Bacteria

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Abstract
SUMMARY The effect of synthetic and naturally occurring polyamines on bacterial growth was studied. The tetra-amine spermine was the most potent anti- bacterial agent and showed maximal activity at high pH values. The anti- bacterial action of the triamines was dependent upon the number of the primary amino groups in the polyamine molecule and was maximal when it contained a -N(CH,),N- moiety. Polyamines, in low concentrations, stimulated the incorporation of (14C)uracil into the nucleic acids of growing bacteria, whereas higher concentrations were inhibitory. In contrast the incorporation of (14C)valine into bacterial proteins was inhibited by polyamines, even in low concentrations.

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