Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis
- 10 October 2006
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 67 (7) , 1288-1290
- https://doi.org/10.1212/01.wnl.0000238107.31364.21
Abstract
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).Keywords
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