Further Toxicity Studies with Methylglucamine Contrast Agents

Abstract
By measuring the cardiovascular effects on dogs of carotid artery injections of contrast media, the toxicity of methylglucamine metrizoate was compared to that of a mixture of calcium and methylglucamine metrizoate. Methlglucamine iothalamate was compared to a dimer of methylglucamine iothalamate. Addition of calcium salts or dimerization did not lower the toxicity of the methylglucamine salts.

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