Structure of the Marek's disease virus BamHI-H gene family: genes of putative importance for tumor induction
- 1 June 1989
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 63 (6) , 2534-2542
- https://doi.org/10.1128/jvi.63.6.2534-2542.1989
Abstract
The BamHI H fragment of Marek9s disease virus (MDV), which has been hypothesized to contain a tumor-inducing gene, was partially sequenced and analyzed for transcriptional activity. Transcription of several RNAs was found to initiate within BamHI-H, with the major transcripts initiating on either side of a putative MDV origin of lytic replication. A 1.8-kilobase gene family found to be produced only by pathogenic MDV was detected, and its transcription map was produced. It is hypothesized that the 1.8-kilobase gene family is directly associated with the tumorigenic potential of MDV. ImagesThis publication has 30 references indexed in Scilit:
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