15‐hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation
- 1 June 1980
- Vol. 15 (6) , 472-474
- https://doi.org/10.1007/bf02534075
Abstract
Using human platelets isolated from their plasma, we showed that 15‐hydroperoxy‐eicosatetraenoic acid (15‐HPETE) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin H2 analog. 15‐HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.This publication has 17 references indexed in Scilit:
- A simple and efficient method for platelet isolation from their plasmaThrombosis Research, 1980
- Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomesBiochimica et Biophysica Acta (BBA) - Enzymology, 1978
- A simple radiochemical assay of thromboxane B2, 12-hydroxyeicosatetraenoic acid (HETE) and 12-hydroxyheptadecatrienoic acid (HHT) synthetized by human plateletsClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATIONThe Lancet, 1977
- The chemical structure of prostaglandin X (prostacyclin)Prostaglandins, 1976
- A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregationProstaglandins, 1976
- Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxidesProstaglandins, 1976
- A new sensitive assay for the measurement of hydroperoxidesAnalytical Biochemistry, 1976
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- Aggregation of Blood Platelets by Adenosine Diphosphate and its ReversalNature, 1962