Regio- and Stereoselective Opening of Phenyloxirane by Lithium Azide: A Direct Access to 2-Azido-1-phenylethanol
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (06) , 403-404
- https://doi.org/10.1055/s-1991-20742
Abstract
Regio-and stereoselective ring opening of styrene oxide (phenyloxirane) at the non-benzylic position was achieved by lithium azide/hexamethylphosphoric triamide. Optically pure (R)-2-azido-1-phenylethanol was obtained from the readily available (R)-phenyloxirane with complete retention of configuration.Keywords
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