Some studies on peptide analogues involving the sulphinamide group
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 2169-2176
- https://doi.org/10.1039/p19910002169
Abstract
The title compounds are of interest as possible transition state inhibitors of peptidases. A route to N(alkylsulphinyl)amino acids is described. A method for generating α-benzamidosulphinamides is reported; a general route to such systems failed owing to the difficulty of removing the protecting group and the apparent instability of α-amino sulphinamides. A crystal structure on the N-phthalimido-protected α-sulphinamide 16a showed the tetrahedral disposition of substituents around the sulphur atom and the deviation from planarity about the sulphinamide nitrogen atom.Keywords
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