RESPONSE OF EXPLANTED CARDIAC MUSCLE TO THYROXINE

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Abstract
Thyroxin, acting on cultures of pulsating fragments of heart muscle removed from 2-day-olc. chick embryos, before the appearance of nerve elements, exerted its typical effect on frequency of pulsation and contracti-bility, bringing about a progressively greater increase in rate, ending in some cases in fibrillation and paralysis. These results indicate that in clinical hyperthyroidism the tachycardia is due to the action of thyroxin directly on the myocardium and not on intervening nerve elements.

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