Q FEVER IN THE UNITED STATES

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Abstract
The preceding articles in this series cover the clinical and epidemiologic aspects of the outbreak of Q fever at Amarillo, Texas, in March 1946. The present report describes the results of complement fixation tests for Q fever obtained with serums from patients infected in this outbreak. The first significant indication that the Amarillo outbreak of illnesses was caused by the strain of rickettsia responsible for Q fever came from complement fixation tests done on convalescent serums. Burnet and Freeman,1 Cox2 and Dyer, Topping and Bengtson3 utilized direct rickettsial agglutination, while Bengtson4 first applied the complement fixation technic using yolk sac antigen in serologic tests for Q fever. With serums obtained from patients infected in the Amarillo outbreak, a modified Kolmer, quantitative complement fixation procedure with overnight ice box fixation was employed. The Q fever antigen5 was prepared from a strain isolated in 1935 from Dermacentor

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