Influence of physostigmine upon consolidation of memory in mice.

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Abstract
The influence of physostigmine upon the consolidation process was investigated. Male mice of a DBA/2J strain were trained to escape shock in a Y-maze. Physostigmine (.4 mg/kg, i.p.) impaired a previously learned task 2 days after initial learning but improved performance 11 days after initial learning. The impairment of memory found on day 3 was transitory and no longer evident once the drug was no longer active in an animal''s system. The day 12 facilitory effect was examined and the same results were found as day 3. The results of the experimentation tend to support an inhibitory or motivational hypothesis rather than a consolidation hypothesis.