Autoimmune Response to Acetylcholine Receptor
- 25 May 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 180 (4088) , 871-872
- https://doi.org/10.1126/science.180.4088.871
Abstract
Injection of rabbits with acetylcholine receptor highly purified from the electric organ of Electrophorus electricus emulsified in complete Freund's adjuvant resulted in the production of precipitating antibody to acetylcholine receptor. After the second injection of antigen, the animals developed the flaccid paralysis and abnormal electromyographs characteristic of neuromuscular blockade. Treatment with the anticholinesterases edrophonium or neostigmine dramatically alleviated the paralysis and the fatigue seen in electromyography.Keywords
This publication has 2 references indexed in Scilit:
- The Metabolism of Fatty Acids in the Rat VI. Arachidonic AcidActa Physiologica Scandinavica, 1965
- Myasthenia Gravis: A New HypothesisScottish Medical Journal, 1960