Bactericidal activity of cefadroxil, cephalexin, and cephradine in an in vitro pharmacokinetic model.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (7) , 718-726
- https://doi.org/10.7164/antibiotics.32.718
Abstract
Cefadroxil resembles cephalexin and cephradine in spectrum of antibacterial activity but differs in human pharmacokinetic properties. Whether the latter are likely to affect activity in vivo was assessed by determining bactericidal activity against clinical isolates under conditions simulating the variation of drug concentration in the blood stream after an oral dose of 500 mg to adults. In this kinetic model, cefadroxil was more active than cephalexin or cephradine against Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, Proteus mirabilis, Haemophilus influenzae and 1 of 2 strains of Escherichia coli. The other strain of E. coli was virtually unaffected by the cephalosporins. S. pyrogenes was equally susceptible to all 3 cephalosporins. Analysis of the results suggests that the pharmacokinetic properties of an antibiotic affect its activity in blood stream, provided the susceptibility of the infecting organism is concentration-dependent within the range of drug concentrations occurring in serum.This publication has 1 reference indexed in Scilit:
- Laboratory evaluation of FR10612, a new oral cephalosporin derivative.The Journal of Antibiotics, 1976