Hypercalciuria and Hypercalcemia Complicating Immobilization

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Abstract
In this issue of the Journal (132:560-564, 1978), Rosen and his colleagues reemphasize a phenomenon long known but often forgotten, the dissolution of bone that results from immoblization. They described six boys, between 4 and 16 years old, in whom hypercalcemia and hypercalciuria occurred after bed rest and cast application for fracture of dislocation of weight-bearing bones. Others have found hypercalciuria, with or without hypercalcemia, in association with paralysis,1 severe burns,2 extensive casting for conditions other than fracture,3 the weightless state enjoyed (or at least endured) by astronauts,4 and voluntary bed rest, with5 or without, body spicas.6 In some of these studies, decreased bone density was evident by radiography1 or by gamma scanning6; early and extensive osteoporosis characterized the large series of burn patients described by Evans and Smith.7 Although most subjects have been adults, the few reports involving children suggest that

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