Terpenoids ofSinularia.: Chemistry and Biomedical Applications
Open Access
- 1 January 2005
- journal article
- research article
- Published by Taylor & Francis in Pharmaceutical Biology
- Vol. 43 (3) , 253-269
- https://doi.org/10.1080/13880200590928852
Abstract
The soft coral genus Sinularia. is one of the most widely distributed soft corals. It constitutes a dominant portion of the biomass in the tropical reef environment. Sinularia. elaborates a rich harvest of secondary metabolites including sesquiterpenes, diterpenes, polyhydroxylated steroids, and polyamine compounds. These metabolites were recently shown to possess a range of biological activities such as antimicrobial, anti-inflammatory, and cytotoxic activities. During the past decade, Sinularia. has yielded many new structures with novel skeletons. Several of the previously published secondary metabolites have been reexamined for their pharmacological properties, and the results strongly support further investigations. The current article reviews the terpenoids of the soft coral genus Sinularia. and their pharmacological significance.Keywords
This publication has 80 references indexed in Scilit:
- Five novel norcembranoids from Sinularia leptoclados and S. parvaTetrahedron, 2003
- Marine pharmacology in 2000: Antitumor and cytotoxic compoundsInternational Journal of Cancer, 2003
- Bishomoisomandapamate, a New Tetracyclic Diterpenoid from a New Species of the Sinularia Genus of the Indian OceanJournal of Chemical Research, 1999
- Rare aromadendrane diterpenoids from a new soft coral species of Sinularia genus of the Indian OceanTetrahedron, 1997
- New Cembranoid Lactones from the Indian Ocean Soft Coral Sinularia flexibilisJournal of Natural Products, 1997
- Cardiac and vascular responses of isolated rat tissues treated with diterpenes from Sinularia flexibilis (Coelenterata: Octocorallia)Toxicon, 1996
- Sandensolide: A New Dihydroxycembranolide from the Soft Coral,Sinularia sandensisVerseveldt of the Indian OceanNatural Product Letters, 1995
- Terpenoid and steroid constituents of the Indian ocean soft coral Sinularia maximaTetrahedron, 1995
- Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonistsJournal of Medicinal Chemistry, 1991
- Lophotoxins: Irreversible active‐site‐directed inhibitors of nicotinic acetylcholine receptorsDrug Development Research, 1991