A Comparative Study of Enzymuria, in the Rat, of the Drug Combinations Amikacin/Vancomycin and Amikacin/Teicoplanin

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Abstract
The aim of this study was to compare nephrotoxicity of the combinations ami-kacinlvancomycin and amikacinlteicoplanin. Eighteen male Wistar rats were divided into 3 groups of 6 animals each. The first group received 50 mg-kg-1 of amikacin (i.m. route) and 100 mg-kg-1 of vancomycin (i.p. route). The second group received 50 mg-kg-1 of amikacin (i.m. route) and 40 mg-kg-1 of teicoplanin (i.p. route). The third group received an isotonic solution of sodium chloride. The antibiotics were injected for a period of 6 days. Urine samples of animals were taken 24 h before the beginning of the experiment, then every day, throughout the duration of the treatment (6 days), continuing for an additional 3 days following completion of the administration of the drugs. There were no significant modifications in the urinary excretions of alanine aminopeptidase and the creatinine between the 3 groups; but in the group receiving amikacinlteicoplanin, we observed between days 3 and 8 an increase in the excretion of N-acetyl-β-D-glucosaminidase when compared to the group receiving amikacin/vancomycin (p ≤ 0.05) and to the control group (p ≤ 0.07).