Diastereo- and enantio-selective synthesis of dihydro- and tetrahydro-pyrimidines. A new strategy for the asymmetric synthesis of β-amino ketones and γ-amino alcohols
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 410b-412
- https://doi.org/10.1039/c3988000410b
Abstract
Chiral 1,2-dihydro-(3) and 1,2,3,6-tetrahydro-pyrimidines (4) have been synthesized by reaction of 3-aminoalk-2-enimines (1) with chiral aldehydes, the structure of (4) being confirmed by an X-ray crystal structure determination of a reduction product; a new strategy for the asymmetric synthesis of β-amino ketones (2) and γ-amino alcohols (6) with two or three chiral centres is described.Keywords
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