Suxamethonium Sensitivity and Segregation of Human Serum Cholinesterase Variants at Locus(Ch1) Among Twelve British Families

Publisher Website
Google Scholar
Abstract
Sera from 39 individuals with suxamethonium apnea were examined. The likelihood of the normal cholinesterase:dibucaine resistant cholinesterase .**GRAPHIC**. heterozygotes developing suxamethonium apnea was calculated. The results indicate that 1 in 4000 normal homozygotes and 1 in 400 .**GRAPHIC**. heterozygotes develop suxamethonium apnea. The period of suxamethonium apnea in these individuals was shorter than usually seen in .**GRAPHIC**. homozygotes. An approximate estimate of the frequency of the fluoride resistant cholinesterase .**GRAPHIC**. and silent cholinesterase locus .**GRAPHIC**. genes was also calculated. Twelve British families of these suxamethonium apnea propositi were examined. The inheritance pattern in all these samilies was of the Mendelian type. Three of these families were found to be segregating for the rarer .**GRAPHIC**. gene and 2 for .**GRAPHIC**. gene, respectively. The .**GRAPHIC**. and .**GRAPHIC**. are alleles determining the synthesis of usual and atypical cholinesterase with the likelihood of .**GRAPHIC**. heterozygotes having occasional suxamethonium apnea. There may be cholinesterase variants besides dibucaine and fluoride-resistant, silent and C-5.