Delayed Brain Damage in Adult Monkeys from Radiation in the Therapeutic Range

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Abstract
Twenty-one adult Macaca mulatta that received 6000 rad of supervoltage X irradiation in 30 fractions, alternate sides of the brain being exposed on alternate days, showed widely scattered minute necrotic lesions in the forebrain white matter in 1 of 3 monkeys at 33 wk, 2 of 3 at 52 wk, and 2 of 3 at 104 wk. With passage of time there was an increasing number of lesions with a trend toward mineralization except for those that extended into the cerebral cortex. Accompanying the necrotic lesions were focal vascular endothelial hyperplasia and patches of telangiectasis.

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