Modafinil in Diurnal Sleepiness. A Study of 123 Patients
Open Access
- 1 December 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Sleep
- Vol. 17 (suppl_8) , S113-S115
- https://doi.org/10.1093/sleep/17.suppl_8.s113
Abstract
The efficacy of modafinil, a psychostimulant drug acting on postsynaptic a-\ adrenergic receptors, as a treatment for excessive daytime sleepiness was studied in 123 patients. Subjects included 94 narcoleptic patients (76 with cataplexy), 23 hypersomnia patients and 6 patients with disrupted nocturnal sleep (DNS) and excessive daytime sleepiness (EDS). Clinical efficacy of the treatment on each symptom (EDS, cataplexy and DNS) was evaluated on a four-point scale from excellent to absent. The effectiveness of modafinil as a treatment for EDS was excellent in 17% of all patients, good in 63%, fair in 17% and absent in 3%. The incidence of side effects was rather low (14 of 123 patients) and most of them disappeared (11 patients) when doses were reduced.Keywords
This publication has 0 references indexed in Scilit: