Loss of Heterozygosity on Chromosomes 1 and 11 in Sporadic Pheochromocytomas
- 1 June 1990
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 81 (6-7) , 632-638
- https://doi.org/10.1111/j.1349-7006.1990.tb02620.x
Abstract
Molecular genetic analysis was performed with 20 oncogene probes and 32 polymorphic DNA probes on tumor DNA samples from seven pheochromocytomas; namely, one multiple endocrine neoplasia type 2B, and two familial and four sporadic pheochromocytomas. No amplification or rearrangement of the oncogenes was detected in any of the tumors. However, loss of heterozygosity on chromosome 1p, 11p or 11q was detected in these cases. In addition, a locus related to ETS1 was deleted in two of the sporadic tumors. These results suggest that pheochromocytomas may be genetically heterogeneous, and that inactivation of unknown genes on chromosome 1p, 11p or 11q may contribute to their development.Keywords
This publication has 31 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Gene losses in human tumoursNature, 1988
- The Approaching Era of the Tumor Suppressor GenesScience, 1987
- Deletion of genes on chromosome 1 in endocrine neoplasiaNature, 1987
- Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkageNature, 1987
- A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10Nature, 1987
- Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic ExpressionScience, 1987
- Report of the Committee on Human Gene Mapping by Recombinant DNA techniques (Part 1 of 9)Cytogenetic and Genome Research, 1987
- A case of congenital aniridia and familial pheochromocytoma—With special reference to aniridia-Wilms' tumor syndromeJournal of Human Genetics, 1982